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Automated Vaccine Production

Raman analysis plays a vital role in pharmaceutical development by identifying polymorphs and analyzing crystallinity with high precision. It supports drug formulation and development by offering detailed molecular insights. This technique aids in counterfeit drug detection, raw material identification, and final product characterization. Raman spectroscopy ensures quality control during drug manufacturing and process optimization. It also enables non-destructive tablet coating analysis for consistent pharmaceutical performance.

 Raman Spectroscopy Analysis in Pharmaceutical Science and Technology

Microscopic Cell Analysis

Polymorph and Crystallinity Analysis

  • API characterization is vital for drug stability, solubility, and bioavailability, but traditional milling or spray-drying methods affect morphology and crystallinity.

  • Raman spectroscopy (including low-frequency Raman) enables detection of polymorphs, API–excipient differentiation, and monitoring of recrystallization or phase transformations.

  • It provides real-time, high-resolution insights into crystalline or amorphous states, molecular interactions, and drug stability, especially when combined with computational modelling.

Lab Testing Procedure

Raman Analysis  in Process Control

  • Drug manufacturing requires strict monitoring since minor variations affect quality and safety.

  • Raman spectroscopy ensures real-time monitoring of API distribution, solid dispersions, and scale-up validation with high chemical selectivity.

  • In vaccine production, it enables label-free, continuous monitoring and quantification of viral particles with high specificity, even in complex aqueous environments

Lab Worker

Raman Spectroscopy in Formulation Development

  • Formulation development requires understanding API–excipient interactions and ensuring homogeneity for stable, specific drugs.

  • Raman spectroscopy enables direct, non-destructive quantification (e.g., ciprofloxacin in eye drops), monitors degradation, and supports freeze-drying research.

  • Combined with MD simulation and multivariate analysis, it provides molecular-level insights to optimize excipient selection, stability, and formulation monitoring

Scientist using microscope

Raman Analysis in Final Product Characterization

  • Final drug characterization is crucial to assess API or excipient distribution and study protein conformation, unfolding, and aggregation.

  • Raman spectroscopy enables real-time tracking of protein structure, stability, and formulation effects for better comparability studies.

  • In biologicals and freeze-dried products, it ensures molecular integrity, distinguishes amorphous and crystalline forms, and supports advanced delivery system design

Pile of Pills

Raman Analysis in Counterfeit drug detection

  • Counterfeit drugs from poor manufacturing practices risk patient safety, side effects, and even mortality.

  • Conventional detection methods are slow, limiting large-scale identification.

  • Raman spectroscopy with chemometric models like PCA enables rapid, non-destructive detection of API variations and authenticity, even through the packaging

Raw Meat with Rosemary

Raman Analysis in Raw Material Identification

  • Correct raw material identification and proper packaging are essential to ensure drug safety and performance.

  • Spatially Offset Raman Spectroscopy (SORS) enables non-destructive detection through opaque packaging, ideal for APIs, vaccines, and contaminated syrups.

  • Along with Low-Frequency Raman, it provides rapid, portable, and chemical-specific insights into solid-state changes, contaminants, and authenticity

Doctor using tablet

Raman Analysis in Tablet Coating Analysis

  • Tablet coating ensures protection of the drug and Identification by color for dosage accuracy, but even slight changes affect quality and API measurement.

  • Coatings often weaken Raman signals, making API uniformity hard to assess.

  • Raman spectroscopy with Target Factor Analysis (TFA) enables accurate coating thickness and API analysis without solvents, offering clear surface sensitivity and bulk evaluation

​Raman Spectroscopy in Various Science Disciplines

  1. Raman analysis in Chemistry

  2. Raman analysis in Physics

  3. Raman analysis in Botany

  4. Raman analysis in Zoology

  5. Raman analysis in Biotechnology

  6. Raman analysis in Microbiology

  7. Raman analysis in Biochemistry

  8. Raman analysis in Dentistry

  9. Raman analysis in Agriculture Science

  10. Raman analysis in Environmental Science

  11. Raman analysis in Food Science and Technology

  12. Raman analysis in Geology

  13. Raman analysis in Forensic Science

  14. Raman analysis in Pharmaceutical Science and Engineering

  15. Raman analysis in Marine Science

  16. Raman analysis in Earth Science

  17. Raman analysis in Nano Science and Nano Technology

  18. Raman analysis in Material Science

  19. Raman analysis in Archaelogy

  20. Raman analysis in Architecture

​Applications Raman Spectroscopy in Various  Engineering Disciplines

  1. Raman analysis in Mechanical Engineering

  2. Raman analysis in Civil Engineering

  3. Raman analysis in Electrical Engineering

  4. Raman analysis in Chemical Engineering

  5. Raman analysis in Biomedical Engineering

  6. Raman analysis in Aeronautical Engineering

  7. Raman analysis in Mining Engineering

  8. Raman analysis in Petroleum Engineering

  9. Raman analysis in Metallurgy

  10. Raman analysis in Dairy Technology

  11. Raman analysis in Energy Science and Engineering

  12. Raman analysis in Polymer Science and Technology

  13. Raman analysis in Biomaterials

  14. Raman analysis in Textile Engineering

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